ea0034s2.2 | The upside of glucocorticoids in metabolism (Supported by <emphasis role="italic">Journal of Endocrinology</emphasis>) | SFEBES2014
Cummins Carolyn
, Patel Rucha
, Tsai Ricky
, Orellana Arturo
Synthetic glucocorticoids (GCs) including dexamethasone (Dex) are potent anti-inflammatory drugs. However, long-term use of GCs results in deleterious side effects such as hyperglycemia, hepatosteatosis, and insulin resistance. The nuclear hormone receptors LXRα and LXRβ are known for their important roles in modulating whole-body cholesterol homeostasis. Recently, we have shown that liver X receptor β (LXRβ) knockout mice are protected against Dex-induced ...